Heather Locklear - Hormone Imbalance?
October 2, 2008 by Candice Lane, M.D.
Filed under News, Reviews, and Interviews
Heather Locklear was arrested yesterday for driving under the influence of a controlled substance, presumably the pharmaceutical medication she is taking for anxiety and depression.
In July, she spent a month in a spa-like treatment facility in Arizona for anxiety and depression. Articles implied she was already on medication and needed it adjusted. Certainly her recent public divorce is a reason for situational depression.
With all due respect, I have one question. Has Heather had her hormones checked? Now this might bring a collective groan, but think about it. Locklear is almost 47, well into the perimenopause and hormone loss. She looks young and beautiful, but our bodies have a relentless “biological clock” that cannot be ignored. We know that testosterone and progesterone are the first hormones to decline. Testosterone is linked to maintaining emotional shield and may prevent panic attacks. Progesterone deficiency causes irritability, mood swings, depression, and insomnia. Progesterone has a calming effect on the body by stimulating the calming GABA receptors in the brain. Add a little loss of estrogen which stimulates calming serotonin production (the same as those antidepressants are supposed to be doing), and emotional lability, weepiness, and depression can follow.
The FDA has warned that anti-depressants may increase depression and suicidality.
Medications like hormonal birth control or Prempro only make matters worse because progestins in these medications inhibit the production of the body’s progesterone and occupy progesterone receptors. I have had several patients lately on hormonal birth control come in with depression. They are on things like Mirena and Nuvaring, both of which secrete potent progestins (not progesterone) in the circulation that occupy progesterone receptors and deplete progesterone thereby preventing the calming effect of progesterone and natural hormonal balance. This effect may be more pronounced as we get older, since we are also losing our progesterone by our ovaries beginning to shut down. Post-partum depression is associated with a drop in progesterone after childbirth. Giving progesterone post-partum can prevent this depression.
Stress makes matters worse. When we have stress our adrenal glands increase our production of cortisol which is our hormone that controls our daily sleep-wake cycle and our fight or flight response. The body will use all its resources to make cortisol, a hormone we cannot live without. The body uses progesterone to help make cortisol, so stress situations may make progesterone levels lower. This may be the connection between stress and infertility. Chronic stress gives way to fatigue as the body struggles to keep up with the stress demand. Both adrenal stress and fatigue can further intensify depression through fluctuations in cortisol and progesterone. Relaxation may allow temporary improvement, but the perimenopausal body still continues its relentless progesterone and estrogen decline.
Suzanne Somers’s has called anti-depressants, sleeping pills, and pain medicine, the “menopause cocktail”. As a former member of that club, I can attest to the truth of it. Initially, being uninformed and thinking I was still “young”, I did not put it together. It was only through proactive seeking that I found what was missing and that was my hormones. I recommend a good reading of Suzanne Somers’s “Breakthrough”. With bioidentical hormone replacement we can treat the underlying cause of our mid-life perimenopausal emotional changes and be ourselves again.
I have treated women who were able to throw their antidepressants and sleeping pills away and say “bye-bye” to their therapists once their hormone were replaced and balanced with bioidentical hormones.
Heather, check it out. Your body is changing and yes, you are getting older and losing your hormones. It happens to all of us. Replace and balance your hormones with bioidenticals and you might be able to get off all that pharmaceutical, controlled substance stuff, save yourself the embarrassment of negative publicity and mug shots, and be your lovely self again. What have you got to lose?
Bioidentical Hormones are Safe
October 1, 2008 by Candice Lane, M.D.
Filed under For Women
There is no doubt that there is improvement in the symptoms of menopause by using hormone replacement therapy. It includes elimination of symptoms such as hot flashes and night sweats, reversal of bone loss leading to osteoporosis, improved sleep, emotional stability, libido and quality of life.But extreme confusion revolves about the safety of taking hormones.
Some doctors are telling patients to get off all hormones. Some are prescribing Premarin and Provera, while others are prescribing “bio-identical hormones”. Still others are switching back and forth between the two.
Hormone replacement therapy or HRT is a broad category. Some people use this term to refer to all hormone replacement therapy. When you hear this term in the media, they are generally referring to Premarin and Provera which are not natural to the human body. These drugs are referred to as synthetic hormones because they are synthesized with molecules that do not occur in the human body in nature.
Premarin is a type of estrogen obtained from horse’s urine. Although it is natural to horses, it is a different molecule than occurs in the human body. It is a very potent estrogen that can alleviate many symptoms but has negative effects as well.
Provera is a progestin used to prevent tissue from building up in the uterine lining while taking Premarin. A progestin is NOT progesterone. It is a different molecule. Progestins actually inhibit production of progesterone by the human body and have dangerous effects on the human body.
The new classification of hormone replacement therapy is called bio-identical hormone replacement therapy or BHRT. This therapy includes estrogens and progesterone that are made from soy and wild yams obtaining a compound that has the exact same molecular structure as these substances in the human body… therefore, bio-identical.
The dangers of Synthetic HRT (Premarin and Provera) were discovered in the Women’s Health Initiative Study in 2002.
This study analyzed the outcome of women taking Premarin (conjugated equine estrogen or horse estrogen from pregnant mare’s urine) and Provera (medroxyprogesterone acetate or synthetic progesterone) and found increased rates of breast cancer and cardiovascular disease. Since the drugs used were not bio-identical hormones the results only apply to Premarin and Provera, not BHRT.
Premarin is taken orally. Any oral estrogen can be a problem for heart health. It can activate coagulation and inflammation. Descenci in Circulation in 2005, found that transdermal estrogen does not have this effect.
The main breast cancer problem is the synthetic Provera (medroxyprogesterone). When the Women’s Health Initiative patients who received only Premarin without Provera were analyzed the rate of breast cancer was not increased. (Anderson, JAMA, 2004). This indicated that it was the Provera that caused an increased incidence of breast cancer.
BHRT (bio-identical hormone therapy) does not increase the chance of breast cancer. The main danger of synthetic HRT is the non-bio-identical progestin (Provera).
In the Fournier et al. study in the International Journal of Cancer, 2005 studied 54,000 women who were taking bio-identical estrogen and either bio-identical progesterone or synthetic progestin. The women taking the bio-identical progesterone had a 10% decrease in risk of breast cancer and the women taking artificial progestin had a 40% increase in the risk of breast cancer.
The De Lignieres study from Climacteric 2002 could not show an increased risk of breast cancer with use of bio-identical hormones but showed an increased risk with the use of synthetic progestin (Provera/medroxyprogesterone). In fact, they could not justify stopping BHRT(bio-identical), which is beneficial for quality of life, prevention of bone loss and cardiovascular risk profile without activating coagulation and inflammatory protein synthesis as in users of oral estrogens.
The real problem with synthetic HRT is the synthetic progestin(Provera). In contrast, several studies document that higher progesterone levels during pre-menopausal years or during pregnancy are protective against breast cancer. (Campanoli, Journal of Steroid Biochemistry and Molecular Biology, 2005).
In any case, estrogen should not be taken without progesterone which counters the proliferative tissue effect of estrogen on breast and uterine lining.
Bio-identical hormone therapy, which is different from Premarin and Provera, is safe, effective, and proven beyond any reasonable medical and scientific doubt.
Progesterone Deficiency
September 3, 2008 by Candice Lane, M.D.
Filed under For Women
Although the traditional definition of menopause is 12 months without a period, hormone loss can start 10-15 years before this happens. Testosterone starts declining first, and then progesterone. Estrogen is the last to go and is often signaled by the infamous “hot flash” we’ve all heard about.
Most women start feeling differently from their younger selves in their 40’s when progesterone starts declining. But even young women can have decreased progesterone which can manifest as PMS (premenstrual syndrome), often associated with stress or hormonal birth control. The most common symptoms of decreased progesterone include:
- Anxiety
- Depression
- Irritability
- Insomnia
- Mood swings
- Osteoporosis
- Pain and inflammation (aching joints, back)
- Increasing HDL cholesterol
- Excessive menstruation
- Weight gain or inability to lose weight.
- Fibroids
- Fibrocystic disease of the breast
- Breast tenderness
- Bloating
- Indigestion
- Gas
- Snoring
- Migraine headaches
There are other causes of decreased progesterone besides decreased production. These include:
- Stress
- Antidepressants
- Sugar
- Saturated fats
- Deficiency of vitamins A, B6, C, and Zinc
- Decreased thyroid hormone
- Taking progestins (a synthetic progesterone) in birth control pills and birth control devices, or in Prempro (synthetic hormone replacement)
Natural bioidentical (same molecular structure as in the human body) progesterone
has many beneficial effects including:
- A calming effect
- Helps sleep
- Balances estrogen
- Lowers blood pressure
- Helps the body metabolize fats
- Lowers cholesterol
- Increases scalp hair
- Is a natural diuretic
- Is a natural antidepressant
- Increases metabolic rate
If are experiencing the symptoms of progesterone deficiency, it is important to be tested by a knowledgeable physician to see if you need replacement. Natural bioidentical progesterone replacement may be all you need to start feeling yourself again.



